Thioproperazine: Uses And Side Effects Of This Antipsychotic
Thioproperazine is a typical antipsychotic also known as a neuroleptic, which as such acts by blocking some neurotransmitter receptors such as those responsible for regulating dopamine, which is associated with the reduction of typical manifestations of schizophrenia.
In this article we will see what thioproperazine is and what it is for, as well as some of its indications and possible adverse effects.
Thioproperazine is a drug that belongs to the category of antipsychotics The latter includes chemical compounds that are used especially to eradicate some typical manifestations of the diagnosis of schizophrenia, but also to treat symptoms associated with bipolar disorders, both in episodes of mania and depression, obsessive-compulsive disorders and some manifestations of dementia.
Mechanism of action
Thioproperazine works by blocking dopamine receptors in the central nervous system In this way, it has neuroleptic effects and blocks some thoughts, including delusions and hallucinations. For this reason, the other term by which this type of medication has traditionally been known is neuroleptics.
This neuroleptic action produces a powerful effect on manic excitation, which is why thioproperazine is considered effective in the treatment of motor excitement crises, both in the course of some types of schizophrenia and in the case of some types of epilepsy
The above occurs because thioproperazine acts on the central nervous system, more specifically on the ascending reticular system, the limbic system and the hypothalamus which are subcortical centers fundamental for the activation of various human faculties.
Precisely, the drawback of these drugs is that they have a high probability of causing serious adverse reactions that significantly alter some dimensions of the life of the person who has the diagnosis. It is a type of medication with a high risk of toxicity, so Its use requires strict medical supervision and in some countries it has stopped being marketed.
Presentation and dosage
Thioproperazine is marketed under the name Majeptil. Its composition is found in 10 mg tablets for oral administration Said administration depends on the characteristics and medical history of each person, however, in general, 2 or 3 daily doses of 30-40 mg are prescribed, which are achieved progressively.
Considerations and precautions of this drug
The general recommendation was to maintain surveillance in the case of a history of liver disease as well as in cases of epilepsy and serious cardiovascular diseases, despite risk of causing serious ventricular arrhythmias
Thioproperazine is contraindicated in combination with depressants of the respiratory center, antihypertensives. Its absorption in the body can be decreased by interacting with some common compounds such as salts, oxides and different hydroxides. Likewise, it increases the depressant action of the central nervous system when mixed with other sedatives, chemical compounds derived from morphine, barbiturates, hypnotics, methadone, clonidine and anxiolytics.
As to risks of use during pregnancy There are no studies, so its use is not recommended, especially from the last trimester of the gestational period. The same occurs with respect to its use during the breastfeeding period.
Finally, since it produces a significant alteration in the state of wakefulness and drowsiness, it is important to take precautions when driving or operating heavy machinery.
As we said before, the high probability of generating serious adverse reactions has meant that this substance has been replaced by other types of drugs that have similar functions, with fewer risks of toxicity.
The effects of reducing delusions and hallucinations They are related to the blockade of the dopaminergic centers of the limbic system caused by thioproperazine. In turn, adverse effects related to the nervous system, such as extrapyramidal syndrome, are related to blockage of the striatum.
Some of the adverse effects of thioproperazine are the following:
Extrapyramidal syndrome may also appear, which is characterized by the inability to express oneself through mimicry or gestures, some manifestations similar to those of Parkinson’s, a particular type of gait inclined forward, without arms and with small steps, muscle rigidity, gross tremor during movement. state of rest.
