Trankimazin: Uses And Side Effects Of This Anxiolytic
Trankimazin is one of the anxiolytic type medications which is consumed most frequently. It is an immediate-acting benzodiazepine that is used for the treatment of acute states of anxiety, among other conditions.
We will see in this article what trankimazin is and how it works, as well as its main side effects and contraindications.
Trankimazin is the trade name of a psychotropic drug called “alprazolam”. This same drug is in some places known as Xanax. It is an anxiolytic type medication, that is, it is used for the treatment of symptoms of anxiety and panic attacks
The latter include different physiological reactions that occur constantly and whose control is beyond the person’s will. Specifically, it is prescribed for the treatment of clinical conditions such as generalized anxiety disorder and some phobias such as social phobia.
In the same way, Trankimazin is used for the adaptive treatment and in the case of depressive disorders that present comorbidity with anxiety disorders. In the same sense, it is prescribed for the treatment of anxiety states that accompany medical treatments, such as chemotherapy
But it not only has effects as an anxiolytic. Being a drug with hypnotic properties, Trankimazin works as a muscle relaxant and anticonvulsant The above is derived from its pharmacological properties that place it in the category of benzodiazepines. We will now see how this type of drugs are defined.
In general, anxiolytics have a depressant action on the central nervous system. At a specific level, they can have different effects depending on the type of anxiolytic in question. For example, benzodiazepines, prescribed for short-term anxiety attacks, are the most recently marketed anxiolytics, which replaced barbiturates.
Previously, barbiturates were considered the main medication to treat anxiety symptoms, however, they have been gradually replaced due to the large number of adverse effects they cause.
Among the medications that have replaced barbiturates is precisely Trankimazin, a benzodiazepine whose action is immediate; that is to say, acts quickly on the central nervous system and for the same reason, its effects are short-lived (they can last between 12 and 24 hours).
The latter has represented an advantage over other anxiolytics, because, by acting quickly in the body, the need to take large quantities of the medication is reduced. Likewise, having a short duration the chances of developing drug dependence are reduced
Mechanism of action
Being a benzodiazepine, Trankimazin acts through gamma-aminobutyric acid (GABA) receptors. This last one is one of the main neurotransmitters with inhibitory action
When Trankimazin binds to GABA receptors, this inhibitory action is enhanced, generating sedative or anxiolytic effects in the central nervous system. Therefore, this drug is considered an agonist of benzodiazepine receptors.
In other words, the Trankimazin reduces neuronal activation in some areas of the brain where GABA receptors are present; especially in the limbic system, which is the region associated with anxiety states.
Contraindications
Trankimazin is contraindicated in the case of people who have the following symptoms:
Likewise, it is recommended to suspend its use during pregnancy and lactation, due to the probability that this drug is transmitted in the placenta and breast milk. It is also recommended to avoid the use of heavy machinery and take precautions when driving, due to its sedative effects.
Side effects
Although benzodiazepines have reduced the possibility of suffering adverse effects as well as developing drug dependence (compared to barbiturates), these medications still include the possibility of experiencing secondary manifestations.
In this sense, the main adverse effect caused by trankimazin is drowsiness, fatigue and sedation accompanied by severe headaches and dizziness For this reason, it can cause a decrease in alertness, and an alteration in attention or concentration. Along the same lines, trankimazin can cause difficulties in retaining information in the short term, that is, it can cause some memory problems.
On a physiological level, side effects include vomiting, nausea, blurred vision, hypotension, tremors, urinary incontinence, and altered libido. Other more serious although less frequent effects are sudden mood changes, hallucinations, suicidal ideation, aggressiveness or irritability, and intraocular pressure. In the same sense and as can occur with other psychoactive drugs, there is the possibility of developing paradoxical effects (contrary to what would be expected) such as agitation, hyperactivity, restlessness or elevated states of anxiety.
On the other hand, it is advisable to reduce its intake gradually, to avoid a withdrawal syndrome or a sudden return of previous anxiety manifestations. Likewise, excessive taking of this medication can result in overdose with cardiorespiratory failure.
